Analysis of Complex Traits (ACT)

Full Name: Analysis of Complex Traits ( ACT ):
Version: 1.1
Description: As of 03/17/2000, this package contains the following modules:
- ibd, calculates the proportion of gene shared identical by decent for a nuclear family;
- ibdn, (modified program of ERPA), which implements a method for assessing increased-allele sharing between all pairs of affected relatives within a pedigree;
- multic, multivariate analysis for complex traits;
- ml, estimation of variance components using maximum likelihood;
- ql, estimation of variance components using quasi likelihood.
- relcov, generates first degree relationship coefficients for extended families.
- sim2s, the simulation program that was used to test ACT.
- cage, Cohort Analysis for Genetic Epidemiology
- gh: GeneHunter, heavily modified to assist multipoint calculation using multic
- TDT: TDT programs written in SAS
gcc and f77 compilers are necessary. Executable programs are included for compatible operating system, i.e., Solaris2.6.
Authors: Christopher I. Amos, Mariza de Andrade, Jianfang Chen
web: http://www.epigenetic.org/Linkage/act.html
http download: http://www.epigenetic.org/Linkage/act.tar.gz
ftp download: ftp://www.epigenetic.org/pub/Programs/Act/act.tar.gz
source code language: FORTRAN 77, C++
operating systems: SUN Solaris2.4
executables: ibd, ml, ql, he, ibdn, multic
reference:
Amos et al (1996), "Assessing genetic linkage and association with robust components of variance approaches", Ann.Hum.Genet. 60:143-160 (A Summary in PostScript or PDF format is available)

Amos (1994), "Robust Variance-Components Approach for Assessing Genetic Linkage in Pedigrees", Am.J.Hum.Genet. 54:535-543 (A Summary in PostScript or PDF format is available)

de Andrade M, Amos CI, Thiel TJ. "Methods to estimate genetic parameters for quantitative traits". Genetic Epidemiology 17(1):64-76, 1999 (Complete article is available in PDF format)

Last updated by the Web Master on 03/17/2000