The SPSS code below is for mixed effects modeling for a sib-based linkage and association test that does not require any parental information. It is discussed in the following reference: Allison, D. B., Heo, M., Kaplan, N., & Martin, E. R. (1999). Development of Sibling-based Tests of Linkage in the Presence of Association for Quantitative Traits That Do not Require Parental Information. American Journal of Human Genetics, 64:1754-1764. The three key parameters for the program are: sibship: family id number -- must be the same for the sibling members in a same sibship; g: index for the genotype (not for the allele); y: continuous phenotype values. This SPSS program can also be be used for multi-allelic markers. The SPSS code =============== GLM y BY g sibship /RANDOM = sibship /METHOD = SSTYPE(3) /INTERCEPT = INCLUDE /CRITERIA = ALPHA(.05) /DESIGN . Note; Addtion of covariates (e.g., age) for adjustment can be coded as follows: GLM y BY g sibship with age /RANDOM = sibship /METHOD = SSTYPE(3) /INTERCEPT = INCLUDE /CRITERIA = ALPHA(.05) /DESIGN .